Data Research, Vol. 1, Issue 1, Dec  2017, Pages 19-28; DOI: 10.31058/j.data.2017.11003 10.31058/j.data.2017.11003

Predicting the Effect of Prolonged Dihydrotestosterone and Estradiol Valerate Administration on Male Albino Rats

Data Research, Vol. 1, Issue 1, Dec  2017, Pages 19-28.

DOI: 10.31058/j.data.2017.11003

Acha, Chigozie K 1* , Udochukwu Ahaiwe 2

1 Department of Statistics, Michael Okpara University of Agriculture Umudike, Abia State,Nigeria

2 Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria

Received: 30 November 2017; Accepted: 2 January 2018; Published: 15 January 2018

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Abstract

Benign Prostatic Hyperplasia (BPH) can be chemically induced in male albino rat using a combination of dihydrotestosterone (DHT) and estradiol valerate (ESV). This paper predicts the effect of BHP induction on body weight and prostrate weight of male albino rats. The study used a primary data set of ten male albino rats divided into two groups of five rats each. Group 1 (Test) was administered subcutaneous injection of DHT and ESV dissolved in olive oil once in every two days for 28 days while Group 2 (control) was administered subcutaneous injection of olive oil without DHT and ESV once in every two days for 28 days. The rats were weighed daily and histochemical examination of the prostate was carried out to ascertain the presence of BPH. The result shows that the regression coefficients of the body weight and prostrate weight have positive relationship with BPH and also highly significant at 5% level. This study highlights the predictive potentials of body weight changes as a non-assay marker for BPH in male Wister rat and all the variables are highly statistically significant (p < 0.05). The R –squared and the coefficient of determination are 74.92% and 68% respectively, indicating how much of the total variation in the dependent variable, Benign Prostatic Hyperplasia (BPH) , can be explained by the independent variables Mean Prostrate Weight and Mean Body Weight Test. Also the body weight and the prostate weight prediction result shows that they are statistically significant to BPH, their correlation result established that they are also inversely proportional.

Keywords

Dihydrotestosterone, Estradiol Valerate, Prostrate, Body Weight, Regression Model

Copyright

© 2017 by the authors. Licensee International Technology and Science Press Limited. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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