Applied Chemistry, Vol. 2, Issue 1, Jun  2019, Pages 1-16; DOI: 10.31058/ 10.31058/

A Short Review on Antimicrobial Activity Study on Transition Metal Complexes of Ni Incorporating Schiff Bases

Applied Chemistry, Vol. 2, Issue 1, Jun  2019, Pages 1-16.

DOI: 10.31058/

Md. Saddam Hossain 1 , H. M. Tariqul Islam 1 , Md. Nuruzzaman Khan 1 , Abinash Chandro Sarker 1 , Bijan Mohon Chaki 1 , Abdul Latif 1 , Nasiruddin 2 , Ashraful Alam 3 , C.M. Zakaria 4 , Md. Kudrat-E-Zahan 4*

1 Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh

2 Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh

3 Department of Chemistry, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh

4 Department of Chemistry & Bioengineering, Faculty of Science and Engineering, Iwate University, Japan

Received: 6 December 2017; Accepted: 31 March 2019; Published: 5 June 2019

Full-Text HTML | Download PDF | Views 1508 | Download 905


Schiff bases and their complexes are flexible compounds synthesized from the condensation of an amino compound with carbonyl compounds and extensively used for industrial purposes and also show a broad range of biological activities including antibacterial, antifungal, antiviral, antimalarial, ant proliferative, anti-inflammatory, anticancer, anti-HIV, anthelminthic and antipyretic properties. Many Schiff base complexes show excellent catalytic activity in various reactions and in the presence of moisture. Over the past few years, there have been many reports on their applications in homogeneous and heterogeneous catalysis. The high thermal and moisture stabilities of many Schiff base complexes were useful attributes for their application as catalysts in reactions involving at high temperatures. The activity is usually increased by complexation therefore to understand the properties of both ligands and metal can lead to the synthesis of highly active compounds. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. This review compiles the antimicrobial activity of transition metal complexes of Ni over the few year decades.


Schiff Bases, Nickel Complexes, Antibacterial Activity, Antifungal Activity and Antiviral Activity


© 2017 by the authors. Licensee International Technology and Science Press Limited. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


[1] Natarajan Raman, Sivasangu Sobha, Liviu Mitu. Synthesis, structure elucidation, DNA interaction, biological evaluation, and molecular docking of an isatin-derived tyramine bidentate Schiff base and its metal complexes. Springer, Monatsh Chem., 2012, 143, 1019-1030,

[2] S. Padhye, A. Zahra, S. Ekk et al. Synthesis and characterization of copper(II) complexes of 4-alkyl/aryl- 1,2-naphthoquinones thiosemicarbazones derivatives as potent DNA cleaving agents. Inorganica Chimica Acta, 2005, 358, 2023-2030

[3] Nubia Boechat; Warner B. Kover; Monica M. Bastos; Nelilma C. Romeiro. Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors. Med Chem Res., 2007, 15, 492-510.

[4] Md. Saddam Hossain, C. M. Zakaria, M. M. Haque, and Md. Kudrat-E- Zahan. Spectral and Thermal Characterization with Antimicrobial Activity on Cr(III) and Sn(II) Complexes containing N,O Donor Novel Schiff Base Ligand. International Journal of Chemical Studies., 2016, 4, 08-11

[5] Naik AD; Annigeri SM; Gangadharmath UB; Revankar VK; Mahale VB. Anchoring mercapto-triazoles on dicarbonyl backbone to assemble novel binucleating, acyclic SNONS compartmental ligands. Indian J Chem., 2002, 41: 2046-2053

[6] M. Emayavaramban; K. Kumar; P. Mani; B. Prabhakaran; A. Muthuvel. Synthesis, complexation, spectral and antimicrobial study of some novel 5-bromofluorobenzaldehydeoxime and semicarbazone under ultrasonic irradiation. International Journal of Advanced Chemistry, 2014, 2: 20-23

[7] Busto N; Valladolid J; Aliende C.; Jalón FA.; Manzano BR. Preparation of organometallic ruthenium-arene-diaminotriazine complexes as binding agents to DNA. Chem Asian J. 2012, 7, 788-801.

[8] Ang WH.; Dyson PJ. Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy. Eur J Inorg Chem., 2006, 4003-4018.

[9] Hannon MJ. Metal-based anticancer drugs: From a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biology. Pure Appl Chem., 2007, 79, 2243-2261.

[10] Mejía Vázquez DMDCNavarro S. New Approaches in the Treatment of Cancer. Nova Science Publishers, New York. USA, 2010.

[11] Ramadan AEMM. Macrocyclic nickel (II) complexes: Synthesis, characterization, superoxide scavenging activity and DNA-binding. Journal of Molecular Structure, 2012, 1015, 56-66.

[12] Pothiraj K.; Baskaran T.; Raman N. DNA interaction studies of d9 and d10 metal complexes having Schiff base and polypyridyl ligands. J Coord Chem., 2012, 65, 2110-2126.

[13] Rajendiran V.; Karthik R.; Palaniandavar M.; Stoeckli-Evans H.; Periasamy VS. Mixed-ligand copper(II)-phenolate complexes: effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity. Inorg Chem., 2007, 46, 8208-8221.

[14] Williams RJP.; Frausto da Silva JJR. The Natural Selection of the Chemical Elements, Clarendon Press, Oxford, 1997.

[15] Fraústo da Silva JJR, Williams RJP. The Biological Chemistry of the Elements (2nd edn.), Oxford University Press, Oxford, 2001.

[16] Siegel A, Siegel H, Siegel RKO Nickel and its Surprising Impact in Nature. Wiley, New York, USA, 2007.

[17] Kaim W, Rall. J Copper-A “Modern” Bioelement. Angew Chem Int Ed., 1996, 35, 43-60.

[18] Jaouen G. Bioorganometallics: Biomolecules, Labeling, Medicine. Wiley- VCH, Weinheim, 2006.

[19] Md. Saddam Hossain; C.M. Zakaria; Md. Kudrat-E-Zahan. Synthesis, Spectral and Thermal Characterization of novel Cu(II) Complexes with Two New Schiff Base Ligand towards Potential Biological Application. Der Chemica Sinica, 2017, 8, 380-392.

[20] A.A. Holder. Inorganic pharmaceuticals. Annu Rep Prog Chem, Sect A: Inorg Chem., 2012, 108, 350-368.

[21] Ronconi L.; Sadler PJ. Using coordination chemistry to design new medicines. Coord Chem Rev, 2007, 251, 1633-1648.

[22] Schwietert CW.; McCue JP. Coordination compounds in medicinal chemistry. Coord Chem Rev, 1999, 184, 67-89

[23] Kraatz HB, Metzler-Nolte N Concepts and Models in Bioinorganic Chemistry. Wiley-VCH: Weinheim, Germany, 2006.

[24] A.P. Mishra; H. Purwar; Rajendra K. Jain; S.K. Gupta. Microwave Synthesis, Spectral, Thermal and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Aminothiazole Moiety. E-Journal of Chemistry., 2012, 9(4), 1655-1666.

[25] Narendra Kumar Chaudhary; Parashuram Mishra. Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiphene (αft). Hindawi Publishing Corporation. Journal of Chemistry, 2015, 12.

[26] A.S. Thakar; k. K .Singh; k.T. Joshi; A. M. Pancholi; K.S.Pandya. Synthesis, Characterization and Antibacterial Activity of Schiff Bases and their Metal Complexes Derived from 4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones and 2-Amino-4(4’-methylphenyl)thiazole. E-Journal of Chemistry, 2010, 7, 1396-1406.

[27] Majed M. Hania. Synthesis and Antibacterial Activity of Some Transition Metal Complexes of Oxime, Semicarbazone and Phenylhydrazone. E-Journal of Chemistry, 2009, 6, S508-S514.

[28] M.S.Suresh; V.Prakash. Preparation Characterization and Antibacterial Studies of Chelates of Schiff Base Derived from 4-Aminoantipyrine, Furfural and o-Phenylenediamine. E-Journal of Chemistry, 2011, 8, 1408-1416.

[29] J. Senthil Kumaran; S. Priya; N. Jayachandramani. Synthesis, Spectroscopic Characterization and Biological activities of Transition Metal complexes containing tridentate Schiff base. Journal of Chemistry, 2013, 2015, 10.

[30] Mahendra Yadav; Synthesis, Characterization. Biological Activity of Some Transition Metal Complexes of N-Benzoyl-N-2-thiophenethiocarbohydrazide. International Journal of Inorganic Chemistry, 2012, 8.

[31] Ambit Thakar; Krishnakant Joshi; Kishor Pandya; Arvind Pancholi. Coordination Modes of a Schiff Base Derived from Substituted 2-Aminothiazole with Chromium(III), Manganese(II), Iron(II), Cobalt(II), Nickel(II) and Copper(II) Metal Ions: Synthesis, Spectroscopic and Antimicrobial Studies. E-Journal of Chemistry, 2011, 8, 1750-1764.

[32] Riyadh M. Ahmed, Enaam I. Yousif, Hasan A. Hasan, and Mohamad J. Al-Jeboori, Metal Complexes of Macrocyclic Schiff-Base Ligand: Preparation, Characterization, and Biological Activity. The Scientifc World Journal, 2013, 7.

[33] Nagesh Gunvanthrao Yernale; Mruthyunjayaswamy Bennikallu Hire Mathada. Synthesis, Characterization, Antimicrobial, DNA Cleavage, and In Vitro Cytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety. Bioinorganic Chemistry and Applications, 2014, 17.

[34] Mohammed Khaled bin Break; M. Ibrahim M. Tahir; Karen A. Crouse, and Teng-Jin Khoo, Synthesis, Characterization, and Bioactivity of Schiff Bases and Their Cd2+, Zn2+, Cu2+, and Ni2+ Complexes Derived from Chloroacetophenone Isomers with S-Benzyldithiocarbazate and the X-Ray Crystal Structure of S-Benzyl--N-(4 chlorophenyl)methylenedithiocarbazate. Bioinorganic Chemistry and Applications. 2013, 13.

[35] C. Anitha; C. D. Sheela; P. Tharmaraj; R. Shanmugakala. Studies on Synthesis and Spectral Characterization of Some Transition Metal Complexes of Azo-Azomethine, Derivative of Diaminomaleonitrile. International Journal of Inorganic Chemistry, 2013, 10.

[36] Nora H. Al-Sha’alan. Antimicrobial Activity and Spectral, Magnetic and Thermal Studies of Some Transition Metal Complexes of a Schiff Base Hydrazone Containing a Quinoline Moiety. Molecules, 2007, 12, 1080-1091.

[37] Sulekh Chandra; Deepali Jain; Amit Kumar Sharma; Pratibha Sharma. Coordination Modes of a Schiff Base Pentadentate Derivative of 4-Aminoantipyrine with Cobalt(II), Nickel(II) and Copper(II) Metal Ions: Synthesis, Spectroscopic and Antimicrobial Studies. Molecules, 2009, 14, 174-190.

[38] Yu-Ye Yu; Hui-Duo Xian; Jian-Feng Liu; Guo-Liang Zhao. Synthesis, Characterization, Crystal Structure and Antibacterial Activities of Transition Metal(II) Complexes of the Schiff Base 2-[(4-Methylphenylimino)methyl]-6-methoxyphenol. Molecules, 2009, 14, 1747-1754.

[39] Mohamed Mustafa Ibrahim, Hapipah Mohd Ali, Mahmood Ameen Abdullah and Pouya Hassandarvish. Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats. Molecules, 2012, 17, 12449-12459

[40] Ikechukwu P. Ejidike and Peter A. Ajibade. Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base. Molecule, 2015, 20, 9788-9802.

[41] Ram N. Patel, Yogendra Pratap Singh, Yogendra Singh, Ray J. Butcher, Matthias Zeller, R.K. Bhubon Singh, Oinam U-wang. Syntheses, crystal structures, spectral and DFT studies of copper (II) and nickel(II) complexes with N0-(pyridine-2-ylmethylene) acetohydrazide. Journal of Molecular Structure, 2017, 1136, 157-172

[42] J.R. Anacona, Juan Luis Rodriguez, Juan Camus. Synthesis, characterization and antibacterial activity of a Schiff base derived from cephalexin and sulphathiazole and its transition metal complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 129, 96–102.

[43] A M Qadir. Synthesis, characterization and antibacterial activities of two nickel(II) complexes with xanthate derivatives and N,N,N0,N0- tetramethylethylenediamine as ligands. Transit Met Chem, 2017, 42, 35-39.

[44] Sarat Chandra Kumar; Abhijit Pal; Merry Mitra; V M Manikandamathavanb; Chia-Her Lin; Balachandran Unni Nair And Rajarshi Ghosh. DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex. J. Chem. Sci., 2015, 127, 1375-1381.

[45] Mostafa K. Rabia; Ahmad Desoky M. Mohamad; Nabawia M. Ismail; Ali Abdo Mahmoud. Synthesis, Characterization, DNA Interaction, Thermal And In Vitro Biological Activity Investigation Of Some Ni(II)-Isatin Bishydrazone Complexes. J. Iran Chem Soc., 2014, 11, 1147-1163.

[46] Hamid Goudarziafshar; Majid Rezaeivala; Fayezeh Khosravi; Yunes Abbasityula. Synthesis, characterization and crystal structures of new Zinc(II) and Nickel(II) complexes containing morpholine moiety and their antibacterial studies. J Iran Chem Soc, 2015, 12, 113-119.

[47] H. M. Parekh and M. N. Patel. Preparation of Schiff’s Base Complexes of Mn(II), Co(II), Ni(II),Cu(II), Zn(II), and Cd(II) and Their Spectroscopic, Magnetic, Thermal, and Antifungal Studies. Russian Journal of Coordination Chemistry, 2006, 32, 431-436.

[48] B. Gupta and N. Fahmi. Co(II) and Ni(II) Complexes with Schiff Base Ligands: Synthesis, Characterization, and Biological Activity. Russian Journal of General Chemistry, 2016, 86, 1182-1190.

[49] Juan Anacona; Javier Santaella. Synthesis, magnetic and spectroscopic studies of a Schiff base derived from cephaclor and 1, 2-diaminobenzene and its transition metal complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 115, 800-804

Related Articles